NFL Week 5 Picks Against the Spread, Tips and Predictions

What’s the best ATS bet to make, considering each of the 14 matchups on the NFL’s Week 5 slate? Our favorite choice against the spread is Patriots -1, but we have plenty more tips for you, which could lead to parlay opportunities, below.

NFL Picks Against the Spread – Week 5

Jump to Matchup:

Pick: Patriots -1 vs. Dolphins

Matchup: Miami Dolphins at New England Patriots
Projected Winner & Margin: Patriots by 4.0 points (Bet on this game at BetMGM)
Spread: Patriots -1
Time: 1:00 p.m. ET
Date: Oct. 6
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans +1 vs. Bills

Matchup: Buffalo Bills at Houston Texans
Projected Winner & Margin: Texans by 2.1 points (Bet on this game at BetMGM)
Spread: Bills -1
Time: 1:00 p.m. ET
Date: Oct. 6
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +1.5 vs. Falcons

Matchup: Tampa Bay Buccaneers at Atlanta Falcons
Projected Winner & Margin: Falcons by 0.7 points (Bet on this game at BetMGM)
Spread: Falcons -1.5
Time: 8:15 p.m. ET
Date: Oct. 3
TV Channel: Amazon Prime Video
Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -2.5 vs. Jets

Matchup: New York Jets vs. Minnesota Vikings
Projected Winner & Margin: Vikings by 5.2 points (Bet on this game at BetMGM)
Spread: Vikings -2.5
Time: 9:30 a.m. ET
Date: Oct. 6
TV Channel: NFL Network
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals +2.5 vs. Ravens

Matchup: Baltimore Ravens at Cincinnati Bengals
Projected Winner & Margin: Ravens by 1.2 points (Bet on this game at BetMGM)
Spread: Ravens -2.5
Time: 1:00 p.m. ET
Date: Oct. 6
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -2.5 vs. Cowboys

Matchup: Dallas Cowboys at Pittsburgh Steelers
Projected Winner & Margin: Steelers by 6.0 points (Bet on this game at BetMGM)
Spread: Steelers -2.5
Time: 8:20 p.m. ET
Date: Oct. 6
TV Channel: NBC
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Colts +3 vs. Jaguars

Matchup: Indianapolis Colts at Jacksonville Jaguars
Projected Winner & Margin: Colts by 3.2 points (Bet on this game at BetMGM)
Spread: Jaguars -3
Time: 1:00 p.m. ET
Date: Oct. 6
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos -3 vs. Raiders

Matchup: Las Vegas Raiders at Denver Broncos
Projected Winner & Margin: Broncos by 6.8 points (Bet on this game at BetMGM)
Spread: Broncos -3
Time: 4:05 p.m. ET
Date: Oct. 6
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders -3.5 vs. Browns

Matchup: Cleveland Browns at Washington Commanders
Projected Winner & Margin: Commanders by 4.4 points (Bet on this game at BetMGM)
Spread: Commanders -3.5
Time: 1:00 p.m. ET
Date: Oct. 6
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +3.5 vs. Packers

Matchup: Green Bay Packers at Los Angeles Rams
Projected Winner & Margin: Rams by 0.5 points (Bet on this game at BetMGM)
Spread: Packers -3.5
Time: 4:25 p.m. ET
Date: Oct. 6
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears -4 vs. Panthers

Matchup: Carolina Panthers at Chicago Bears
Projected Winner & Margin: Bears by 7.9 points (Bet on this game at BetMGM)
Spread: Bears -4
Time: 1:00 p.m. ET
Date: Oct. 6
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Saints +5 vs. Chiefs

Matchup: New Orleans Saints at Kansas City Chiefs
Projected Winner & Margin: Chiefs by 4.6 points (Bet on this game at BetMGM)
Spread: Chiefs -5
Time: 8:15 p.m. ET
Date: Oct. 7
TV Channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks -6 vs. Giants

Matchup: New York Giants at Seattle Seahawks
Projected Winner & Margin: Seahawks by 7.0 points (Bet on this game at BetMGM)
Spread: Seahawks -6
Time: 4:25 p.m. ET
Date: Oct. 6
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: 49ers -7.5 vs. Cardinals

Matchup: Arizona Cardinals at San Francisco 49ers
Projected Winner & Margin: 49ers by 10.3 points (Bet on this game at BetMGM)
Spread: 49ers -7.5
Time: 4:05 p.m. ET
Date: Oct. 6
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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