NFL Week 6 Picks Against the Spread, Tips and Predictions

There are 14 matchups on the NFL’s Week 6 schedule, with the Titans (+1) among the best bets against the spread, according to our projections. For more tips, including parlay opportunities, keep reading.

NFL Picks Against the Spread – Week 6

Jump to Matchup:

Pick: Titans +1 vs. Colts

Matchup: Indianapolis Colts at Tennessee Titans
Projected Winner & Margin: Colts by 0.6 points (Bet on this game at BetMGM)
Spread: Colts -1
Time: 1:00 p.m. ET
Date: Oct. 13
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears -2.5 vs. Jaguars

Matchup: Jacksonville Jaguars vs. Chicago Bears
Projected Winner & Margin: Bears by 13.5 points (Bet on this game at BetMGM)
Spread: Bears -2.5
Time: 9:30 a.m. ET
Date: Oct. 13
TV Channel: NFL Network
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Jets +2.5 vs. Bills

Matchup: Buffalo Bills at New York Jets
Projected Winner & Margin: Jets by 3.2 points (Bet on this game at BetMGM)
Spread: Bills -2.5
Time: 8:15 p.m. ET
Date: Oct. 14
TV Channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Broncos +3 vs. Chargers

Matchup: Los Angeles Chargers at Denver Broncos
Projected Winner & Margin: Broncos by 6.4 points (Bet on this game at BetMGM)
Spread: Chargers -3
Time: 4:05 p.m. ET
Date: Oct. 13
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -3 vs. Raiders

Matchup: Pittsburgh Steelers at Las Vegas Raiders
Projected Winner & Margin: Steelers by 8.7 points (Bet on this game at BetMGM)
Spread: Steelers -3
Time: 4:05 p.m. ET
Date: Oct. 13
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Seahawks +3.5 vs. 49ers

Matchup: San Francisco 49ers at Seattle Seahawks
Projected Winner & Margin: Seahawks by 1.0 points (Bet on this game at BetMGM)
Spread: 49ers -3.5
Time: 8:15 p.m. ET
Date: Oct. 10
TV Channel: Amazon Prime Video
Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Saints +3.5 vs. Buccaneers

Matchup: Tampa Bay Buccaneers at New Orleans Saints
Projected Winner & Margin: Saints by 0.2 points (Bet on this game at BetMGM)
Spread: Buccaneers -3.5
Time: 1:00 p.m. ET
Date: Oct. 13
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cowboys +3.5 vs. Lions

Matchup: Detroit Lions at Dallas Cowboys
Projected Winner & Margin: Cowboys by 3.1 points (Bet on this game at BetMGM)
Spread: Lions -3.5
Time: 4:25 p.m. ET
Date: Oct. 13
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants +3.5 vs. Bengals

Matchup: Cincinnati Bengals at New York Giants
Projected Winner & Margin: Giants by 5.7 points (Bet on this game at BetMGM)
Spread: Bengals -3.5
Time: 8:20 p.m. ET
Date: Oct. 13
TV Channel: NBC
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -5 vs. Cardinals

Matchup: Arizona Cardinals at Green Bay Packers
Projected Winner & Margin: Packers by 9.6 points (Bet on this game at BetMGM)
Spread: Packers -5
Time: 1:00 p.m. ET
Date: Oct. 13
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Falcons -6 vs. Panthers

Matchup: Atlanta Falcons at Carolina Panthers
Projected Winner & Margin: Falcons by 17.2 points (Bet on this game at BetMGM)
Spread: Falcons -6
Time: 4:25 p.m. ET
Date: Oct. 13
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders +6.5 vs. Ravens

Matchup: Washington Commanders at Baltimore Ravens
Projected Winner & Margin: Commanders by 0.4 points (Bet on this game at BetMGM)
Spread: Ravens -6.5
Time: 1:00 p.m. ET
Date: Oct. 13
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Texans -7 vs. Patriots

Matchup: Houston Texans at New England Patriots
Projected Winner & Margin: Texans by 11.0 points (Bet on this game at BetMGM)
Spread: Texans -7
Time: 1:00 p.m. ET
Date: Oct. 13
TV Channel: CBS
Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Eagles -8.5 vs. Browns

Matchup: Cleveland Browns at Philadelphia Eagles
Projected Winner & Margin: Eagles by 20.0 points (Bet on this game at BetMGM)
Spread: Eagles -8.5
Time: 1:00 p.m. ET
Date: Oct. 13
TV Channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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